Professor Frederic Meunier

Professor

Queensland Brain Institute

Affiliate Professorial Res Fellow

Institute for Molecular Bioscience
f.meunier@uq.edu.au
+61 7 334 66373

Overview

Professor Frederic Meunier obtained his Masters degree in Neurophysiology at the Paris XI University, France in 1992 and completed his Ph.D in Neurobiology at the CNRS in Gif-sur-Yvette, France in 1996. He was the recipient of a European Biotechnology Fellowship and went on to postgraduate work at the Department of Biochemistry at Imperial College (1997-1999) and at Cancer Research UK (2000-2002) in London, UK. After a short sabbatical at the LMB-MRC in Cambridge (UK), he became a group leader at the School of Biomedical Sciences at the University of Queensland (Australia) in 2003. He joined the Queensland Brain Institute of the University of Queensland in 2007 and obtained an NHMRC senior research fellowship in 2009 renewed in 2014 with promotion. He became Professor in 2014 at the Queensland Brain Institute and is currently part of the Centre for Ageing Dementia Research.

Research Interests

  • Nanoscale organisation of the synapse
    Use of single molecule imaging to track botulinum neurotoxin interaction with the neuronal membrane Use of single molecule imaging to uncover the change in presynaptic nanoscale organization occurring during neurotransmitter release (endocytosis) Use of single molecule imaging to uncover the change in presynaptic nanoscale organization occurring during neurotransmitter release (exocytosis)
  • Track epigenetic modifications elicited by synaptic plasticity associated with memory
    Understanding how memory is encoded in neurons require a deeper understanding of how pre- and post-synaptic plasticity affect the mesoscale organisation of our DNA via epigenetic modifications.
  • PROJECT 3: Synaptic remodelling.
    Neurotrophins are signalling molecules capable of inducing neurite outgrowth but it is not clear how they can affect the overall physiology of the neuron when the soma is located as far away as 1 metre from the site of uptake. Our strategy will be to establish a versatile and accessible in vitro model based on compartmentalised cultures (Campenot chambers) closely matching the reality of the neuromuscular system. The principle is to monitor and analyse neurite outgrowth and establishment of functional synapses with myocytes in communicant chambers. The binding, uptake, packaging of neurotrophic factors, their retrograde transport and eventual delivery will be investigated with a series of technical approaches ranging from classical binding studies to imaging of synaptic activity, time-lapse fluorescent video microscopy imaging of fluorescently-tagged factors and immunocytochemical approaches.
  • Nanoscale initiation of neurodegenerative diseases
    Use of single molecule imaging to uncover the change in Fyn and associated signalling cascade occurring during the development of Alzheimer’s disease Use of single molecule imaging to uncover the change in a-synuclein nanoscale organization in neurons associated with various disease-causing mutations

Qualifications

  • Doctor of Philosophy, Universite de Paris XI - Sud
  • Master of Science, Universite de Paris XI - Sud
  • Bachelor of Science, Université de Nice Sophia-Antipolis

Publications

View all Publications

Grants

View all Grants

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

Book Chapter

  • Joensuu, Merja, Martínez-Mármol, Ramon, Mollazade, Mahdie, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Single-Molecule Imaging of Recycling Synaptic Vesicles in Live Neurons. Single Molecule Microscopy in Neurobiology. (pp. 81-114) New York, NY United States: Springer. doi: 10.1007/978-1-0716-0532-5_5

  • Narayana, Vinod K., Kvaskoff, David and Meunier, Frederic A. (2017). New developments in free fatty acids and lysophospholipids: decoding the role of phospholipases in exocytosis. Lipidomics of stem cells. (pp. 191-206) edited by Alice Pebay and Raymond C.B. Wong. Cham, Switerland: Spinger Nature.

  • Harper, Callista B., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2015). Exploiting endocytic pathways to prevent bacterial toxin infection. The comprehensive sourcebook of bacterial protein toxins. (pp. 1072-1094) edited by Daniel Ladant, Michel R. Popoff and Joseph E. Alouf . Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-800188-2.00040-9

  • Wen, Peter J., Osborne, Shona L. and Meunier, Frederic A. (2012). Phosphoinositides in neuroexocytosis and neuronal diseases. Current topics in microbiology and immunology. (pp. 87-98) edited by Marco Falasca and Peter K. Vogt. Amsterdam, Netherlands: Springer. doi: 10.1007/978-94-007-5025-8_4

  • Meunier, Frederic A., Mattei, Cesar F. and Molgo, Jordi (2009). Marine toxins potently affecting neurotransmitter release¹. Marine Toxins as Research Tools. (pp. 159-186) edited by Fusetani, Nobuhiro and Kem, William. Berlin & Heidelberg: Springer - Verlag. doi: 10.1007/978-3-540-87895-7_6

  • Meunier, Frederic A. and Osborne, Shona L. (2008). Lipids and Secretory Vesicle Exocytosis. Molecular Mechanisms of Neurotransmitter Release. (pp. 239-261) edited by Wang, Zhao-Wen. United States: Springer. doi: 10.1007/978-1-59745-481-0

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision