The University of Queensland

Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy

Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019) Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232. doi:10.1016/j.biomaterials.2019.119232

Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells

Simpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019) Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, . doi:10.1039/c9bm00957d

Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?

Song, Danzi, Cui, Jiwei, Ju, Yi, Faria, Matthew, Sun, Huanli, Howard, Christopher B., Thurecht, Kristofer J. and Caruso, Frank (2019) Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?. ACS Applied Materials & Interfaces, 11 32: 28720-28731. doi:10.1021/acsami.9b10304

Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments

Islam, Jiaul, Riley, Blake T., Fercher, Christian, Jones, Martina L., Buckle, Ashley M., Howard, Christopher B., Cox, Rosalind P., Bell, Toby D. M., Mahler, Stephen and Corrie, Simon R. (2019) Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments. Analytical Chemistry, 91 12: 7631-7638. doi:10.1021/acs.analchem.9b00445

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

Cui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019) Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies. Advanced Healthcare Materials, e1801607. doi:10.1002/adhm.201801607

Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning

Alfaleh, Mohamed, Arora, Neetika, Yeh, Michael, de Bakker, Christopher, Howard, Christopher, Macpherson, Philip, Allavena, Rachel, Chen, Xiaoli, Harkness, Linda, Mahler, Stephen and Jones, Martina (2019) Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning. Antibodies, 8 1: 15. doi:10.3390/antib8010015

RNA interference to enhance radiation therapy: targeting the DNA damage response

Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018) RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439 14-23. doi:10.1016/j.canlet.2018.09.011

A SERS microfluidic platform for targeting multiple soluble immune checkpoints

Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018) A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126 178-186. doi:10.1016/j.bios.2018.10.044

Multiplexed SERS detection of soluble cancer protein biomarkers with gold-silver alloy nanoboxes and nanoyeast single-chain variable fragments

Li, Junrong, Wang, Jing, Grewal, Yadveer S, Howard, Christopher B, Raftery, Lyndon J, Mahler, Stephen, Wang, Yuling and Trau, Matt (2018) Multiplexed SERS detection of soluble cancer protein biomarkers with gold-silver alloy nanoboxes and nanoyeast single-chain variable fragments. Analytical Chemistry, 90 17: 10377-10384. doi:10.1021/acs.analchem.8b02216

Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant

Pham, Huong Thi, Nhiep, Nguyen Thi Hanh, Vu, Thu Ngoc Minh, Huynh, TuAnh Ngoc, Zhu, Yan, Huynh, Anh Le Diep, Chakrabortti, Alolika, Marcellin, Esteban, Lo, Raquel, Howard, Christopher B., Bansal, Nidhi, Woodward, Joshua J., Liang, Zhao-Xun and Turner, Mark S. (2018) Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant. PLOS Genetics, 14 8: e1007574. doi:10.1371/journal.pgen.1007574

Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach

Fontaine, Frank R., Goodall, Stephen, Prokop, Jeremy W., Howard, Christopher B., Moustaqil, Mehdi, Kumble, Sumukh, Rasicci, Daniel T., Osborne, Geoffrey W., Gambin, Yann, Sierecki, Emma, Jones, Martina L., Zuegg, Johannes, Mahler, Stephen and Francois, Mathias (2018) Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10 4: 1-11. doi:10.1080/19420862.2018.1451288

Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands

Tang, Jie, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Huang, Leaf and Xu, Zhi Ping (2018) Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands. Nanoscale, 10 9: 4258-4266. doi:10.1039/c7nr08644j

Bispecific antibody-functionalized upconversion nanoprobe

He, Hao, Howard, Christopher B., Chen, Yinghui, Wen, Shihui, Lin, Gungun, Zhou, Jiajia, Thurecht, Kristofer J. and Jin, Dayong (2018) Bispecific antibody-functionalized upconversion nanoprobe. Analytical Chemistry, 90 5: 3024-3029. doi:10.1021/acs.analchem.7b05341

Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models

Alfaleh, Mohamed A., Howard, Christopher B., Sedliarou, Ilya, Jones, Martina L., Gudhka, Reema, Vanegas, Natasha, Weiss, Jocelyn, Suurbach, Julia H., de Bakker, Christopher J., Milne, Michael R., Rumballe, Bree A., MacDiarmid, Jennifer A., Brahmbhatt, Himanshu and Mahler, Stephen M. (2017) Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models. Plos One, 12 10: e0186137. doi:10.1371/journal.pone.0186137

Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing

Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2017) Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing. Microchemical Journal, 137 231-237. doi:10.1016/j.microc.2017.10.012

Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions

Tayeb, Hossam H, Piantavigna, Stefania, Howard, Christopher B, Nouwens, Amanda, Mahler, Stephen M, Middelberg, Anton P J, He, Lizhong, Holt, Stephen A and Sainsbury, Frank (2017) Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions. Soft matter, 13 43: 7953-7961. doi:10.1039/c7sm01614j

Recent Advances in the Generation of Antibody-Nanomaterial Conjugates

Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2017) Recent Advances in the Generation of Antibody-Nanomaterial Conjugates. Advanced healthcare materials, 7 1: 1-25. doi:10.1002/adhm.201700607

Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning

Alfaleh, Mohamed A., Jones, Martina L., Howard, Christopher B. and Mahler, Stephen M. (2017) Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning. Antibodies, 6 3: 1-19. doi:10.3390/antib6030010

Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10

Alsultan, Abdulkarim M., Chin, David Y., Howard, Christopher B., de Bakker, Christopher J., Jones, Martina L. and Mahler, Stephen M. (2016) Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10. Scientific Reports, 5 37348: 37348. doi:10.1038/srep37348

Biosimilars approved for treatment of inflammatory rheumatological diseases

Mahler, Stephen M., Wardiana, Andri, Jones, Martina L., De Bakker, Christopher J., Graham, Garry G. and Howard, Christopher B. (2016) Biosimilars approved for treatment of inflammatory rheumatological diseases. International Journal of Rheumatic Diseases, 19 11: 1043-1048. doi:10.1111/1756-185X.13037

Targeted Nanomaterials: Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016)

Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016) Targeted Nanomaterials: Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016). Advanced Healthcare Materials, 5 16: 1994-1994. doi:10.1002/adhm.201670084

Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies

Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016) Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies. Advanced Healthcare Materials, 5 16: 2055-2068. doi:10.1002/adhm.201600263

Targeting membrane proteins for antibody discovery using phage display

Jones, Martina L., Alfaleh, Mohamed A., Kumble, Sumukh, Zhang, Shuo, Osborne, Geoffrey W., Yeh, Michael, Arora, Neetika, Hou, Jeff Jia Cheng, Howard, Christopher B., Chin, David Y. and Mahler, Stephen M. (2016) Targeting membrane proteins for antibody discovery using phage display. Scientific Reports, 6 26240. doi:10.1038/srep26240

Biosensing made easy with PEG-targeted bi-specific antibodies

Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. A., Carrascosa, Laura G., Thurecht, Kristofer J., Mahler, Stephen M. and Trau, Matt (2016) Biosensing made easy with PEG-targeted bi-specific antibodies. Chemical Communications, 52 33: 5730-5733. doi:10.1039/C6CC01916A

Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells

Tang, Jie, Li, Li, Howard, Christopher B., Mahler, Stephen M., Huang, Leaf and Xu, Zhi Ping (2015) Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells. Journal of Materials Chemistry B, 3 33: 6805-6812. doi:10.1039/c5tb00912j

Production and characterisation of recombinant human chaperonin 10 for treatment of inflammatory disease

Naylor, Dean J., Hunt, Ben, Guidolin, Angelo, Hey, Allan W., Bastiras, Stan, de Bakker, Christopher J., Chin, David Y., Marquis, Christopher P., Lambert, Daniel, Howard, Christopher B., Dobbin, Caroline A. and Mahler, Stephen M. (2015) Production and characterisation of recombinant human chaperonin 10 for treatment of inflammatory disease. Process Biochemistry, 50 10: 1669-1679. doi:10.1016/j.procbio.2015.06.022

Nanocell targeting using engineered bispecific antibodies.

Taylor, Karin, Howard, Christopher B., Jones, Martina L., Sedliarou, Ilya, MacDiarmid, Jennifer, Brahmbhatt, Himanshu, Munro, Trent P. and Mahler, Stephen M. (2014) Nanocell targeting using engineered bispecific antibodies.. mAbs, 7 1: 53-65. doi:10.4161/19420862.2014.985952

Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells

Buecheler, Jakob W., Howard, Christopher B., de Bakker, Christopher J., Goodall, Stephen, Jones, Martina L, Win, Thinzar, Peng, Tao, Tan, Cher Heng, Chopra, Akhil, Mahler, Stephen M and Lim, Sierin (2014) Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells. Journal of Chemical Technology and Biotechnology, 90 7: 1230-1236. doi:10.1002/jctb.4545

An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer

Goodall, Stephen, Howard, Christopher B., Jones, Martina L., Munro,Trent, Jia, Zhongfan, Monteiro, Michael J and Mahler, Stephen (2014) An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer. Journal of Chemical Technology and Biotechnology, 90 7: 1222-1229. doi:10.1002/jctb.4509

Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP

Mo, Jinyao, Boyle, Joseph P., Howard, Christopher B., Monie, Tom P., Davis, Beckley K. and Duncan, Joseph A. (2012) Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. Journal of Biological Chemistry, 287 27: 23057-23067. doi:10.1074/jbc.M112.344283

Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production

Johnson, BJ, Le, TTT, Dobbin, CA, Banovic, T, Howard, CB, Flores, FDL, Vanags, D, Naylor, DJ, Hill, GR and Suhrbier, A (2005) Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. Journal of Biological Chemistry, 280 6: 4037-4047. doi:10.1074/jbc.M411569200