Journal Article: Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy
Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019) Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232. doi:10.1016/j.biomaterials.2019.119232
Simpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019) Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, . doi:10.1039/c9bm00957d
Journal Article: Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?
Song, Danzi, Cui, Jiwei, Ju, Yi, Faria, Matthew, Sun, Huanli, Howard, Christopher B., Thurecht, Kristofer J. and Caruso, Frank (2019) Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?. ACS Applied Materials & Interfaces, 11 32: 28720-28731. doi:10.1021/acsami.9b10304
Smart affinity membranes for manufacture of high value therapeutic proteins
(2019–2022) ARC Linkage Projects
Evaluation of recombinant biologics for immune modulation
(2019–2020) Servatus Biopharmaceuticals
Expression of recombinant proteins in mammalian cells
(2019) Servatus Biopharmaceuticals
Active targeting of PEGylated nanoparticles to tumour cells for effective for cancer therapy
Doctor Philosophy
Comparability studies of biopharmaceuticals produced by fed-batch or perfusion culture
Doctor Philosophy
Targeting nanoparticles to tumour cells with antibodies for enhanced tumour uptake
Doctor Philosophy
Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019) Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232. doi:10.1016/j.biomaterials.2019.119232
Simpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019) Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, . doi:10.1039/c9bm00957d
Song, Danzi, Cui, Jiwei, Ju, Yi, Faria, Matthew, Sun, Huanli, Howard, Christopher B., Thurecht, Kristofer J. and Caruso, Frank (2019) Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?. ACS Applied Materials & Interfaces, 11 32: 28720-28731. doi:10.1021/acsami.9b10304
Islam, Jiaul, Riley, Blake T., Fercher, Christian, Jones, Martina L., Buckle, Ashley M., Howard, Christopher B., Cox, Rosalind P., Bell, Toby D. M., Mahler, Stephen and Corrie, Simon R. (2019) Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments. Analytical Chemistry, 91 12: 7631-7638. doi:10.1021/acs.analchem.9b00445
Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies
Cui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019) Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies. Advanced Healthcare Materials, e1801607. doi:10.1002/adhm.201801607
Alfaleh, Mohamed, Arora, Neetika, Yeh, Michael, de Bakker, Christopher, Howard, Christopher, Macpherson, Philip, Allavena, Rachel, Chen, Xiaoli, Harkness, Linda, Mahler, Stephen and Jones, Martina (2019) Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning. Antibodies, 8 1: 15. doi:10.3390/antib8010015
Retooling Phage Display with Electrohydrodynamic Nanomixing and Nanopore Sequencing
Raftery, Lyndon J, Howard, Christopher B, Grewal, Yadveer S, Vaidyanathan, Ramanathan, Jones, Martina L, Anderson, Will, Korbie, Darren, Duarte, Tania, Duc Cao, Minh, Nguyen, Son Hoang, Coin, Lachlan JM, Mahler, Stephen M and Trau, Matt (2019) Retooling Phage Display with Electrohydrodynamic Nanomixing and Nanopore Sequencing. Lab on a Chip, . doi:10.1039/c9lc00978g
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019) Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, . doi:10.1039/c9an01450k
RNA interference to enhance radiation therapy: targeting the DNA damage response
Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018) RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439 14-23. doi:10.1016/j.canlet.2018.09.011
A SERS microfluidic platform for targeting multiple soluble immune checkpoints
Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018) A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126 178-186. doi:10.1016/j.bios.2018.10.044
Li, Junrong, Wang, Jing, Grewal, Yadveer S, Howard, Christopher B, Raftery, Lyndon J, Mahler, Stephen, Wang, Yuling and Trau, Matt (2018) Multiplexed SERS detection of soluble cancer protein biomarkers with gold-silver alloy nanoboxes and nanoyeast single-chain variable fragments. Analytical Chemistry, 90 17: 10377-10384. doi:10.1021/acs.analchem.8b02216
Pham, Huong Thi, Nhiep, Nguyen Thi Hanh, Vu, Thu Ngoc Minh, Huynh, TuAnh Ngoc, Zhu, Yan, Huynh, Anh Le Diep, Chakrabortti, Alolika, Marcellin, Esteban, Lo, Raquel, Howard, Christopher B., Bansal, Nidhi, Woodward, Joshua J., Liang, Zhao-Xun and Turner, Mark S. (2018) Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant. PLOS Genetics, 14 8: e1007574. doi:10.1371/journal.pgen.1007574
Fontaine, Frank R., Goodall, Stephen, Prokop, Jeremy W., Howard, Christopher B., Moustaqil, Mehdi, Kumble, Sumukh, Rasicci, Daniel T., Osborne, Geoffrey W., Gambin, Yann, Sierecki, Emma, Jones, Martina L., Zuegg, Johannes, Mahler, Stephen and Francois, Mathias (2018) Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10 4: 1-11. doi:10.1080/19420862.2018.1451288
Tang, Jie, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Huang, Leaf and Xu, Zhi Ping (2018) Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands. Nanoscale, 10 9: 4258-4266. doi:10.1039/c7nr08644j
Bispecific antibody-functionalized upconversion nanoprobe
He, Hao, Howard, Christopher B., Chen, Yinghui, Wen, Shihui, Lin, Gungun, Zhou, Jiajia, Thurecht, Kristofer J. and Jin, Dayong (2018) Bispecific antibody-functionalized upconversion nanoprobe. Analytical Chemistry, 90 5: 3024-3029. doi:10.1021/acs.analchem.7b05341
Alfaleh, Mohamed A., Howard, Christopher B., Sedliarou, Ilya, Jones, Martina L., Gudhka, Reema, Vanegas, Natasha, Weiss, Jocelyn, Suurbach, Julia H., de Bakker, Christopher J., Milne, Michael R., Rumballe, Bree A., MacDiarmid, Jennifer A., Brahmbhatt, Himanshu and Mahler, Stephen M. (2017) Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models. Plos One, 12 10: e0186137. doi:10.1371/journal.pone.0186137
Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing
Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2017) Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing. Microchemical Journal, 137 231-237. doi:10.1016/j.microc.2017.10.012
Tayeb, Hossam H, Piantavigna, Stefania, Howard, Christopher B, Nouwens, Amanda, Mahler, Stephen M, Middelberg, Anton P J, He, Lizhong, Holt, Stephen A and Sainsbury, Frank (2017) Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions. Soft matter, 13 43: 7953-7961. doi:10.1039/c7sm01614j
Recent Advances in the Generation of Antibody-Nanomaterial Conjugates
Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2017) Recent Advances in the Generation of Antibody-Nanomaterial Conjugates. Advanced healthcare materials, 7 1: 1-25. doi:10.1002/adhm.201700607
Alfaleh, Mohamed A., Jones, Martina L., Howard, Christopher B. and Mahler, Stephen M. (2017) Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning. Antibodies, 6 3: 1-19. doi:10.3390/antib6030010
Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10
Alsultan, Abdulkarim M., Chin, David Y., Howard, Christopher B., de Bakker, Christopher J., Jones, Martina L. and Mahler, Stephen M. (2016) Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10. Scientific Reports, 5 37348: 37348. doi:10.1038/srep37348
Biosimilars approved for treatment of inflammatory rheumatological diseases
Mahler, Stephen M., Wardiana, Andri, Jones, Martina L., De Bakker, Christopher J., Graham, Garry G. and Howard, Christopher B. (2016) Biosimilars approved for treatment of inflammatory rheumatological diseases. International Journal of Rheumatic Diseases, 19 11: 1043-1048. doi:10.1111/1756-185X.13037
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016) Targeted Nanomaterials: Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016). Advanced Healthcare Materials, 5 16: 1994-1994. doi:10.1002/adhm.201670084
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016) Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies. Advanced Healthcare Materials, 5 16: 2055-2068. doi:10.1002/adhm.201600263
Targeting membrane proteins for antibody discovery using phage display
Jones, Martina L., Alfaleh, Mohamed A., Kumble, Sumukh, Zhang, Shuo, Osborne, Geoffrey W., Yeh, Michael, Arora, Neetika, Hou, Jeff Jia Cheng, Howard, Christopher B., Chin, David Y. and Mahler, Stephen M. (2016) Targeting membrane proteins for antibody discovery using phage display. Scientific Reports, 6 26240. doi:10.1038/srep26240
Biosensing made easy with PEG-targeted bi-specific antibodies
Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. A., Carrascosa, Laura G., Thurecht, Kristofer J., Mahler, Stephen M. and Trau, Matt (2016) Biosensing made easy with PEG-targeted bi-specific antibodies. Chemical Communications, 52 33: 5730-5733. doi:10.1039/C6CC01916A
Tang, Jie, Li, Li, Howard, Christopher B., Mahler, Stephen M., Huang, Leaf and Xu, Zhi Ping (2015) Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells. Journal of Materials Chemistry B, 3 33: 6805-6812. doi:10.1039/c5tb00912j
Naylor, Dean J., Hunt, Ben, Guidolin, Angelo, Hey, Allan W., Bastiras, Stan, de Bakker, Christopher J., Chin, David Y., Marquis, Christopher P., Lambert, Daniel, Howard, Christopher B., Dobbin, Caroline A. and Mahler, Stephen M. (2015) Production and characterisation of recombinant human chaperonin 10 for treatment of inflammatory disease. Process Biochemistry, 50 10: 1669-1679. doi:10.1016/j.procbio.2015.06.022
Nanocell targeting using engineered bispecific antibodies.
Taylor, Karin, Howard, Christopher B., Jones, Martina L., Sedliarou, Ilya, MacDiarmid, Jennifer, Brahmbhatt, Himanshu, Munro, Trent P. and Mahler, Stephen M. (2014) Nanocell targeting using engineered bispecific antibodies.. mAbs, 7 1: 53-65. doi:10.4161/19420862.2014.985952
Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells
Buecheler, Jakob W., Howard, Christopher B., de Bakker, Christopher J., Goodall, Stephen, Jones, Martina L, Win, Thinzar, Peng, Tao, Tan, Cher Heng, Chopra, Akhil, Mahler, Stephen M and Lim, Sierin (2014) Development of a protein nanoparticle platform for targeting EGFR expressing cancer cells. Journal of Chemical Technology and Biotechnology, 90 7: 1230-1236. doi:10.1002/jctb.4545
An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer
Goodall, Stephen, Howard, Christopher B., Jones, Martina L., Munro,Trent, Jia, Zhongfan, Monteiro, Michael J and Mahler, Stephen (2014) An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer. Journal of Chemical Technology and Biotechnology, 90 7: 1222-1229. doi:10.1002/jctb.4509
Mo, Jinyao, Boyle, Joseph P., Howard, Christopher B., Monie, Tom P., Davis, Beckley K. and Duncan, Joseph A. (2012) Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. Journal of Biological Chemistry, 287 27: 23057-23067. doi:10.1074/jbc.M112.344283
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production
Johnson, BJ, Le, TTT, Dobbin, CA, Banovic, T, Howard, CB, Flores, FDL, Vanags, D, Naylor, DJ, Hill, GR and Suhrbier, A (2005) Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. Journal of Biological Chemistry, 280 6: 4037-4047. doi:10.1074/jbc.M411569200
Smart affinity membranes for manufacture of high value therapeutic proteins
(2019–2022) ARC Linkage Projects
Evaluation of recombinant biologics for immune modulation
(2019–2020) Servatus Biopharmaceuticals
Expression of recombinant proteins in mammalian cells
(2019) Servatus Biopharmaceuticals
Production and analysis of recombinant therapeutics for immune modulation
(2019) Servatus Biopharmaceuticals
Continuous chromatography system for advanced bioprocessing
(2018) UQ Major Equipment and Infrastructure
ARC Training Centre for Biopharmaceutical Innovation
(2017–2022) ARC Industrial Transformation Training Centres
Provision of research services to Minomic International Ltd
(2017–2018) Minomic International Ltd
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers
(2016–2019) ARC Linkage Projects
Immuno-polymeric drugs for prostate cancer therapy
(2016–2018) NHMRC Project Grant
EGFR targeted nanoparticle feasibility study
(2016–2017) Samyang Biopharmaceuticals Corporation
Active targeting of PEGylated nanoparticles to tumour cells for effective for cancer therapy
Doctor Philosophy — Principal Advisor
Other advisors:
Comparability studies of biopharmaceuticals produced by fed-batch or perfusion culture
Doctor Philosophy — Principal Advisor
Other advisors:
Targeting nanoparticles to tumour cells with antibodies for enhanced tumour uptake
Doctor Philosophy — Principal Advisor
Other advisors:
Engineering new affinity probes for diagnostic approaches
Doctor Philosophy — Associate Advisor
Other advisors:
Antibodies Against Intracellular Targets
Doctor Philosophy — Associate Advisor
Other advisors:
Development of novel antibody diagnostics and therapeutics
Doctor Philosophy — Associate Advisor
Other advisors:
Targeting the nanocell to cancer cells using antibodies
Doctor Philosophy — Associate Advisor
Other advisors:
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Doctor Philosophy — Associate Advisor
Other advisors:
Isolation and characterisdation of novel antibodies against cell-surface biomarkers
Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
(2019) Master Philosophy — Associate Advisor
(2018) Doctor Philosophy — Associate Advisor
Other advisors:
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
(2018) Doctor Philosophy — Associate Advisor
Other advisors:
Refining Nanocarrier Emulsions for Pharmaceutical Use
(2018) Doctor Philosophy — Associate Advisor
Development and Application of Novel Biosensor Technologies
(2017) Doctor Philosophy — Associate Advisor
Other advisors:
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
(2017) Master Philosophy — Associate Advisor
Other advisors: