The University of Queensland

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Bridgford, Jessica L., Lee, Su Min, Lee, Christine M. M., Guglielmelli, Paola, Rumi, Elisa, Pietra, Daniela, Wilcox, Stephen, Chhabra, Yash, Rubin, Alan F., Cazzola, Mario, Vannucchi, Alessandro M., Brooks, Andrew J., Call, Matthew Edwin and Call, Melissa Joy (2020). Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning. Blood, 135 (4), 287-292. doi: 10.1182/blood.2019002561

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity

Campos, Livia Weijenborg, Zenatti, Priscila Pini, Pissinato, Leonardo Granato, Rodrigues, Gisele Olinto Libanio, Artico, Leonardo Luís, Guimarães, Thais Rafael, Archangelo, Leticia Fröhlich, Martínez, Leandro, Brooks, Andrew J. and Yunes, Jose Andres (2019). Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity. Blood, 133 (11), 1259-1263. doi: 10.1182/blood-2018-09-872945

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352

Cytokine receptors

Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2018). Cytokine receptors. Endocrinology: principles of endocrinology and hormone action. (pp. 157-185) edited by Antonino Belfiore and Derek LeRoith. Amsterdam, The Netherlands: Springer. doi: 10.1007/978-3-319-44675-2_8

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Brooks, Andrew J., Dai, Wei, O’Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344 (6185) 1249783, 1249783.1-1249783.12. doi: 10.1126/science.1249783

The growth hormone receptor: mechanism of activation and clinical implications

Brooks, Andrew J. and Waters, Michael J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews Endocrinology, 6 (9), 515-525. doi: 10.1038/nrendo.2010.123

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Rowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008). An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 (6), 740-747. doi: 10.1038/ncb1737

Cytokine receptors

Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2018). Cytokine receptors. Endocrinology: principles of endocrinology and hormone action. (pp. 157-185) edited by Antonino Belfiore and Derek LeRoith. Amsterdam, The Netherlands: Springer. doi: 10.1007/978-3-319-44675-2_8

Cytokine Receptors

Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe B. (2017). Cytokine Receptors. Endocrinology (Switzerland). (pp. 1-29) Springer Science and Business Media Deutschland GmbH. doi: 10.1007/978-3-319-27318-1_8-2

Growth hormone-binding proteins

Herington, Adrian C. and Brooks, Andrew J. (2014). Growth hormone-binding proteins. Reference module in biomedical research. (pp. 390-395) edited by Michael Caplan. Philadelphia, PA, United States: Elsevier. doi: 10.1016/B978-0-12-801238-3.04053-8

The interdomain region of dengue NS5 protein interacts with NS3 and host proteins

Brooks, Andrew J., Johansson, Magnus, Criswell, Erin, Jans, David A. and Vasudevan, Subhash G. (2002). The interdomain region of dengue NS5 protein interacts with NS3 and host proteins. Dengue Bulletin. (pp. 155-161) New Delhi, India.: WHO Regional Office for South-East Asia.

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Chhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490

Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN

Butler, Liesl, Lee, Christine, Magor, Graham William, Morris, Rhiannon, Tallack, Michael, Lam, Charlene, Ivey, Adam, Lin, Jane, Deng, Zihao, Grigg, Andrew, Mason, Jane, Perchard, Malaika, Weston, Helen, Cummings, Nik, Brooks, Andrew, Babon, Jeffrey J, Murphy, Andrew J, Salmon, Jessica M and Perkins, Andrew Charles (2022). Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN. Blood, 140 (S1), 1093-1094. doi: 10.1182/blood-2022-159416

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 12 (1) 7032, 7032. doi: 10.1038/s41467-021-26983-5

GHR signalling: Receptor activation and degradation mechanisms

Chhabra, Yash, Lee, Christine M. M., Mueller, Alexandra Franziska and Brooks, Andrew J. (2021). GHR signalling: Receptor activation and degradation mechanisms. Molecular and Cellular Endocrinology, 520 111075, 1-11. doi: 10.1016/j.mce.2020.111075

Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G

Brooks, Andrew J., Ishikawa, Mayumi, Fernández‐Rojo, Manuel A., Vivian, Julian P., Rossjohn, Jamie and Waters, Michael J. (2020). Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G. Hepatology, 73 (3) hep.31531, 1239-1239. doi: 10.1002/hep.31531

JAK-STAT signalling pathway in cancer

Brooks, Andrew J. and Putoczki, Tracy (2020). JAK-STAT signalling pathway in cancer. Cancers, 12 (7) 1971, 1971-3. doi: 10.3390/cancers12071971

Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G

Ishikawa, Mayumi, Brooks, Andrew J., Fernández-Rojo, Manuel A., Medina, Johan, Chhabra, Yash, Minami, Shiro, Tunny, Kathryn A., Parton, Robert G., Vivian, Julian P., Rossjohn, Jamie, Chikani, Viral, Ramm, Grant A., Ho, Ken K. Y. and Waters, Michael J. (2020). Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G. Hepatology, 73 (2) hep.31297, 759-775. doi: 10.1002/hep.31297

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Bridgford, Jessica L., Lee, Su Min, Lee, Christine M. M., Guglielmelli, Paola, Rumi, Elisa, Pietra, Daniela, Wilcox, Stephen, Chhabra, Yash, Rubin, Alan F., Cazzola, Mario, Vannucchi, Alessandro M., Brooks, Andrew J., Call, Matthew Edwin and Call, Melissa Joy (2020). Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning. Blood, 135 (4), 287-292. doi: 10.1182/blood.2019002561

Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity

Chhabra, Yash, Nelson, Caroline N., Plescher, Monika, Barclay, Johanna L., Smith, Aaron G., Andrikopoulos, Sof, Mangiafico, Salvatore, Waxman, David J., Brooks, Andrew J. and Waters, Michael J. (2019). Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (5), fj201802328R-6430. doi: 10.1096/fj.201802328R

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity

Campos, Livia Weijenborg, Zenatti, Priscila Pini, Pissinato, Leonardo Granato, Rodrigues, Gisele Olinto Libanio, Artico, Leonardo Luís, Guimarães, Thais Rafael, Archangelo, Leticia Fröhlich, Martínez, Leandro, Brooks, Andrew J. and Yunes, Jose Andres (2019). Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity. Blood, 133 (11), 1259-1263. doi: 10.1182/blood-2018-09-872945

The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects

Dehkhoda, Farhad , Lee, Christine M. M. , Medina, Johan and Brooks, Andrew J. (2018). The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects. Frontiers in Endocrinology, 9 (35) 35, 35. doi: 10.3389/fendo.2018.00035

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352

Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136)

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005

Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017

STAT5 activation in the dermal papilla is important for hair follicle growth phase induction

Legrand, Julien M. D., Roy, Edwidge, Ellis, Jonathan J., Francois, Mathias, Brooks, Andrew J. and Khosrotehrani, Kiarash (2016). STAT5 activation in the dermal papilla is important for hair follicle growth phase induction. Journal of Investigative Dermatology, 136 (9), 1781-1791. doi: 10.1016/j.jid.2016.04.014

Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells

Stewart, Teneale A., Azimi, Iman, Brooks, Andrew J., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells. The International Journal of Biochemistry and Cell Biology, 76, 64-74. doi: 10.1016/j.biocel.2016.05.007

Uropathogenic Escherichia coli engages CD14-dependent signaling to enable bladder macrophage-dependent control of acute urinary tract infection

Carey, Alison J., Sullivan, Matthew J., Duell, Benjamin L., Crossman, David K., Chattopadhyay, Debasish., Brooks, Andrew J., Tan, Chee K., Crowley, Michael., Sweet, Matthew J., Schembri, Mark A. and Ulett, Glen C. (2015). Uropathogenic Escherichia coli engages CD14-dependent signaling to enable bladder macrophage-dependent control of acute urinary tract infection. The Journal of infectious diseases, 213 (4), 659-668. doi: 10.1093/infdis/jiv424

Exploiting Hydrophobicity for Efficient Production of Transmembrane Helices for Structure Determination by NMR Spectroscopy

Bugge, Katrine, Steinocher, Helena, Brooks, Andrew J., Lindorff-Larsen, Kresten and Kragelund, Birthe B. (2015). Exploiting Hydrophobicity for Efficient Production of Transmembrane Helices for Structure Determination by NMR Spectroscopy. Analytical Chemistry, 87 (18), 9126-9131. doi: 10.1021/acs.analchem.5b02365

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

Haxholm, Gitte W, Nikolajsen, Louise F, Olsen, Johan G, Fredsted, Jacob, Larsen, Flemming H, Goffin, Vincent, Pedersen, Stine F, Brooks, Andrew J, Waters, Michael J and Kragelund, Birthe B (2015). Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes. Biochemical Journal, 468 (3), 495-506. doi: 10.1042/BJ20141243

JAK2 activation by growth hormone and other cytokines

Waters, Michael J. and Brooks, Andrew J. (2015). JAK2 activation by growth hormone and other cytokines. Biochemical Journal, 466 (1), 1-11. doi: 10.1042/BJ20141293

Rewriting the mechanism of JAK2 activation

Brooks, Andrew J. and Waters, Michael J. (2015). Rewriting the mechanism of JAK2 activation. Cell Cycle, 14 (3), 285-286. doi: 10.1080/15384101.2015.1006533

Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance

Dingwall, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015). Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 (12) 1000320, 1-8. doi: 10.4172/2157-7633.1000320

A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors

Waters, Michael J., Brooks, Andrew J. and Chhabra, Yash (2014). A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors. JAK-STAT, 3 (e29569), 1-6. doi: 10.4161/jkst.29569

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Brooks, Andrew J., Dai, Wei, O’Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344 (6185) 1249783, 1249783.1-1249783.12. doi: 10.1126/science.1249783

Why don't some dwarves get cancer?

Waters, Micheal and Brooks, Andrew (2014). Why don't some dwarves get cancer?. Australasian Science, 35 (9), 22-23.

Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling

Fernández Rojo, Manuel, Gongora, Milena, Fitzsimmons, Rebecca L., Martel, Nick, Martin, Sheree D., Nixon, Susan, Brooks, Andrew J., Ikonomopoulou, Maria P., Martin, Sally, Lo, Harriet P., Myers, Stephen A., Restall, Christina, Ferguson, Charles, Pilch, Paul F., McGee, Sean L., Anderson, Robin L., Waters, Michael J., Hancock, John F., Grimmond, Sean M., Muscat, George E. and Parton, Robert G. (2013). Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Reports, 4 (2), 238-247. doi: 10.1016/j.celrep.2013.06.017

Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection

Duell, Benjamin L., Carey, Alison J., Tan, Chee K., Cui, Xiangqin, Webb, Richard I., Totsika, Makrina, Schembri, Mark A., Derrington, Petra, Irving-Rodgers, Helen, Brooks, Andrew J., Cripps, Allan W., Crowley, Michael and Ulett, Glen C. (2012). Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection. Journal of Immunology, 188 (2), 781-792. doi: 10.4049/jimmunol.1101231

Role of the growth hormone–IGF-1 axis in cancer

Chhabra, Yash, Waters, Michael J. and Brooks, Andrew J. (2011). Role of the growth hormone–IGF-1 axis in cancer. Expert Review of Endocrinology and Metabolism, 6 (1), 71-84. doi: 10.1586/eem.10.73

The growth hormone receptor: mechanism of activation and clinical implications

Brooks, Andrew J. and Waters, Michael J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews Endocrinology, 6 (9), 515-525. doi: 10.1038/nrendo.2010.123

The extracellular domain of the growth hormone receptor interacts with coactivator to promote cell proliferation

Conway-Campbell, B. L., Brooks, A. J., Robinson, P. J., Perani, M. and Waters, M. J. (2008). The extracellular domain of the growth hormone receptor interacts with coactivator to promote cell proliferation. Molecular Endocrinology, 22 (9), 2190-2202. doi: 10.1210/me.2008-0128

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Rowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008). An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 (6), 740-747. doi: 10.1038/ncb1737

Growth hormone receptor; mechanism of action

Brooks, Andrew J., Wooh, Jong Wei, Tunny, Kathryn A. and Waters, Michael J. (2008). Growth hormone receptor; mechanism of action. The International Journal of Biochemistry and Cell Biology, 40 (10), 1984-1989. doi: 10.1016/j.biocel.2007.07.008

Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis

Conway-Campbell, B., Wooh, J., Brooks, A., Gordon, D, Brown, R. J., Lichanska, A. M., Chin, H., Barton, C., Boyle, G., Parsons, P., Jans, D. A. and Waters, M. J. (2007). Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proceedings of The National Academy of Sciences of The United States of America, 104 (33), 13331-13336. doi: 10.1073/pnas.0600181104

Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter

Jiménez-Ramírez, Carmilia, Brooks, Andrew J., Forshell, Linus Plym, Yakimchuk, Konstantin, Zhao, Bo, Fulgham, Tacha Zi and Sample, Clare E. (2006). Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter. Journal of Virology, 80 (22), 11200-11208. doi: 10.1128/JVI.00897-06

The interdomain region of dengue NS5 protein interacts with NS3 and host proteins

Brooks, Andrew J., Johansson, Magnus, Criswell, Erin, Jans, David A. and Vasudevan, Subhash G. (2002). The interdomain region of dengue NS5 protein interacts with NS3 and host proteins. Dengue Bulletin, 26, 155-161.

The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin beta 1 and Importin alpha /beta -Recognized Nuclear Localization Signals

Brooks, Andrew J., Johansson, Magnus, John, Anna V., Xu, Yibin, Jans, David A. and Vasudevan, Subhash G. (2002). The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin beta 1 and Importin alpha /beta -Recognized Nuclear Localization Signals. Journal of Biological Chemistry, 277 (39), 36399-36407. doi: 10.1074/jbc.M204977200

A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-β and the viral helicase, NS3

Johansson, Magnus, Brooks, Andrew J., Jans, David A. and Vasudevan, Subhash G. (2001). A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-β and the viral helicase, NS3. Journal of General Virology, 82 (4), 735-745. doi: 10.1099/0022-1317-82-4-735

Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets

Vasudevan, Subhash G., Johansson, Magnus, Brooks, Andrew J., Llewellyn, Lyndon E. and Jans, David A. (2001). Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets. Farmaco, 56 (1-2), 33-36. doi: 10.1016/S0014-827X(01)01014-X

The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site

Forwood, Jade K., Brooks, Andrew, Briggs, Lyndall J., Xiao, Chong-Yun, Jans, David A. and Vasudevan, Subhash G. (1999). The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site. Biochemical and Biophysical Research Communications, 257 (3), 731-737. doi: 10.1006/bbrc.1999.0370

Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity

Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.

Specific domains of LNK (SH2B3) bind and regulate TPOR stability and signalling

Lee, Christine, Brooks, Andrew, Chhabra, Yash and Perkins, Andrew (2019). Specific domains of LNK (SH2B3) bind and regulate TPOR stability and signalling. 48th Annual Scientific Meeting of the Society for Experimental Hematology, Brisbane, Australia, 22-25 August 2019. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2019.06.387

The mechanism of oncogenic mutations in the juxtamembrane and transmembrane region of IL7RA and TPOR/MPL

Brooks, Andrew, Campos, Livia, Lee, Christine, Chhabra, Yash, Bridgford, Jessica, Lee, Su Min, Zenatti, Priscila, Pissinato, Leonardo, Rodrigues, Gisele, Artico, Leonardo, Guimarães, Thais, Archangelo, Leticia, Martínez, Leandro, Slape, Christopher, Call, Matthew, Call, Melissa and Yunes, José (2019). The mechanism of oncogenic mutations in the juxtamembrane and transmembrane region of IL7RA and TPOR/MPL. ISEH 2019, Brisbane, Australia, 22-25 August 2019. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2019.06.332

Class I cytokine receptors: towards the inside

Steinocher, Helena, Bugge, Katrine, Nikolajsen, Louise Fletcher, Lindorff-Larsen, Kresten, Brooks, Andrew and Kragelund, Birthe Brandt (2017). Class I cytokine receptors: towards the inside. 61st Annual meeting of the Biophysical Society, New Orleans, LA, United States, 11-15 February 2017. St. Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2016.11.947

Going downstream - how does GH binding activate JAK2

Brooks, Andrew, Dai, W., O'Mara, M. L., Abankwa, D., Chhabra, Y., Pelekanos, R. A., Gardon, O., Tunny, K. A., Blucher, K. M., Morton, C. J., Parker, M. W., Sierecki, E., Gambin, Y., Gomez, G. A., Alexandrov, K., Wilson, I. A., Doxastakis, M., Mark, A. E. and Waters, M. J. (2016). Going downstream - how does GH binding activate JAK2. Annual Scientific Meeting of the Endocrine Society of Australia, Adelaide, Australia, 23-26 August, 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/cen.13010

Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor

Brooks, Andrew J., O’Mara, Megan L., Dai, Wei, Abankwa, Daniel, Chhabra, Yash, Tunny, Kathryn A., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Haxholm, Gitte W., Nikolajsen, Louise F., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2016). Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor. Biophysical Meeting, Los Angeles, CA, United States, 27 February - 2 March 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.233

A potential role for Janus protein tyrosine kinases in the regulation of epithelial-mesenchymal transition in a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition

Stewart, Teneale A., Azimi, Iman, Davis, Felicity M., Thompson, Erik W., Brooks, Andrew J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). A potential role for Janus protein tyrosine kinases in the regulation of epithelial-mesenchymal transition in a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition. 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX United States, 9-13 December 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS14-P2-07-05

A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor

Brooks, Andrew J, Chhabra, Yash, Abankwa, Daniel, O’Mara, Megan, Dai, Wei, Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Guillermo A. Gomez, Alexandrov, Kirill Kirill, Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor. 2nd Annual Meeting of the International Cytokine and Interferon Society (ICIS), Melbourne, VIC Australia, 26 - 29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.227

Assessment of Janus protein tyrosine kinases as potential regulators of epithelial-mesenchymal transition using a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition

Bassett, John J., Stewart, Teneale A., Azimi, Iman , Davis, Felicity M., Thompson, Erik W., Brooks, Andrew J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Assessment of Janus protein tyrosine kinases as potential regulators of epithelial-mesenchymal transition using a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC Australia, 7-11 December 2014.

Mechanism of activation of JAK2 by growth hormone

Waters, M. J. and Brooks, A. J. (2014). Mechanism of activation of JAK2 by growth hormone. Seventh International Congress of the GRS and the IGF Society, Singapore, 17-20 October 2014. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(14)50035-4

The first cancer-associated variant of the growth hormone receptor

Chhabra, Yash, Wong, Ho Yi, Brooks, Andrew James and Waters, Michael John (2014). The first cancer-associated variant of the growth hormone receptor. Endocrine Society's 96th Annual Meeting and Expo, Chicago, IL, United States, 21-24 June 2014. WASHINGTON: Endocrine Society.

Growth hormone and cell growth

Waters, Michael J. and Brooks, Andrew J. (2012). Growth hormone and cell growth. 6th ESPE Advanced Seminar in Developmental Endocrinology, Bern, Switzerland, 10-11 May 2012. Basel, Switzerland: S. Karger. doi: 10.1159/000341761

Hepatic IGF-I production is regulated by Kupffer cells

Ishikawa, M., Barclay, J. L., Brooks, A. J., McPhee, T. R., Yoshino, G. and Waters, M. J. (2012). Hepatic IGF-I production is regulated by Kupffer cells. Sixth International Congress of the GRS and the IGF Society, Munich, Germany, 17-20 October 2012. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(12)60056-2

Growth hormone receptor: structure function relationships

Waters, Michael J. and Brooks, Andrew J. (2011). Growth hormone receptor: structure function relationships. Switzerland: S. Karger AG. doi: 10.1159/000329138

Role of growth hormone signaling pathways in liver regeneration

Ishikawa, M., McPhee, T. R., Barclay, J. L., Fernandez-Rojo, M., Brooks, A. J. and Waters, M. J. (2010). Role of growth hormone signaling pathways in liver regeneration. Fifth International congress of the GRS and the IGF Society, New York, NY, United States, 3-7 October. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(10)70011-3